By Ulo Langel
One of many significant issues of drug supply is the shortcoming of enormous hydrophilic compounds to go through the lipid membrane of the cellphone, hence making medicines resembling polypeptides and oligonucleotides of constrained healing worth. till lately, the delivery of such molecules into the cytoplasmic and nuclear booths of residing cells appeared target. as a result, the invention that peptides derived from the HIV Tat protein and homeodomain of the Antennapedia transcription issue (penetratin) can translocate around the plasma membrane of stay cells has unfolded fascinating new chances in biomedical research.This ebook fills the necessity for a complete replace of the learn bearing on those really expert peptides, referred to as cell-penetrating peptides (CPPs), to which the drug molecule can connect and go through the mobilephone membrane. Divided into 3 elements, Cell-Penetrating Peptides: methods and functions covers sessions of cell-penetrating peptides; mechanisms of mobilephone penetration, interactions of cell-penetrating peptides with plasma membranes, and lipid types; and purposes of cell-penetrating peptides. those divisions disguise all details from uncomplicated biochemistry to scientific program, together with a transparent description of the overall ideas for mobile uptake of the delivery peptides. The review of labor during this zone will bring about larger designed novel shipping peptides to accomplish the extra winning software of CPPs in learn and treatment.
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Additional info for Cell-Penetrating Peptides: Processes and Applications
4. C. , Conjugation of poly-L-lysine to albumin and horseradish peroxidase: a novel method of enhancing the cellular uptake of proteins, Proc. Natl. Acad. Sci. USA, 75, 1872–1876, 1978. 5. C. , Poly (L-lysine) and poly (D-lysine) conjugates of methotrexate: different inhibitory effect on drug resistant cells, Mol. , 16, 614–622, 1979. 6. , Activation of ribonuclease L by (2′5′)(A)4-poly(L-lysine) conjugates in intact cells, Biochemistry, 25, 3730–3736, 1986. 7. , Specific antiviral activity of a poly(L-lysine)-conjugated oligodeoxyribonucleotide sequence complementary to vesicular stomatitis virus N protein mRNA initiation site, Proc.
USA, 88, 8850–8854, 1991. 39. Eguchi, A. , Protein transduction domain of HIV-1 Tat protein promotes efficient delivery of DNA into mammalian cells, J. Biol. , 276, 26204–26210, 2001. 40. Weissleder, R. , In vivo magnetic resonance imaging of transgene expression, Nat. , 6, 351–355, 2000. 41. Lewin, M. , Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells, Nat. , 18, 410–414, 2000. 42. P. , TAT peptide on the surface of liposomes affords their efficient intracellular delivery even at low temperature and in the presence of metabolic inhibitors, Proc.
276, 3254–3261, 2001. 45. Liu, Y. , Uptake of HIV-1 Tat protein mediated by low-density lipoprotein receptor-related protein disrupts the neuronal metabolic balance of the receptor ligands, Nat. , 6, 1380–1387, 2000. 46. R. , The Tat protein of human immunodeficiency virus type 1, a growth factor for AIDS Kaposi sarcoma and cytokine-activated vascular cells, induces adhesion of the same cell types by using integrin receptors recognizing the RGD amino acid sequence, Proc. Natl. Acad. , 90, 7941–7945, 1993.