Cell Death (Encyclopedia of Life Sciences) - download pdf or read online

By Gerry Melino, David Vaux

This e-book on telephone demise comprises 29 self-contained, peer-reviewed articles written by way of best scientists in each one box. It beneficial properties evaluation articles aimed toward undergraduates and non-specialists, which current uncomplicated info and supply access into the subsequent complicated articles. those complicated articles are written for postgraduate scholars and learn staff, containing exact info and key references permitting the reader to enquire a selected zone in additional intensity. The ebook is a vital source for academic reasons in addition to a reference paintings for knowledgeable researchers within the box. The articles can be to be had electronically as a part of the acclaimed Encyclopedia of lifestyles Sciences (ELS).Key features:Provides a entire review at the examine of programmed mobilephone death.Edited by way of leaders within the field.Clearly written and illustrated articles.Full color throughout.A spin-on to the acclaimed reference paintings, the Encyclopedia of existence technology (ELS).Combines introductory info with assurance of the newest discoveries within the field.Features evaluate point articles for complex scholars or humans new to an issue and extra complicated articles for these requiring extra precise information.Serves as a reference paintings for complicated scholars in addition to researchers during this field.Ideal library buy for technology, scientific, and expertise libraries in academia, govt, and undefined; scientific libraries; networks and consortia overlaying those markets.

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Advances in Experimental Medicine and Biology 406: 21–28. Schumacher B, Hanazawa M, Lee M-H et al. (2005b) Translational repression of C. elegans p53 by GLD-1 regulates DNA damage-induced apoptosis. Cell 120(3): 357–368. 009. Schumacher B, Schertel C, Wittenburg N et al. (2005a) C. elegans ced-13 can promote apoptosis and is induced in response to DNA damage. Cell Death and Differentiation 12(2): 153–161. 4401539. Shaham S and Horvitz HR (1996) An alternatively spliced C. elegans ced-4 RNA encodes a novel cell death inhibitor.

Several of these DNA damage responses can readily be studied in C. elegans. , 2000). Interestingly, the hermaphrodite germline seems Cell Death & 2010, John Wiley & Sons, Ltd. Cell Death in C. elegans to be unique in this respect: neither somatic cells nor the male germline possess the ability to undergo apoptosis following genotoxic stress. , 2000). In contrast to physiological germline apoptosis, however, the BH-3only domain protein EGL-1 is required for apoptotic cell death following IR. , 2000).

Other modules – the ‘addiction modules’ – encode a toxin and an antidote that are both retained by the infected cell. The antidote is constantly cleaved by a bacterial protease, coupling the survival of the infected cell to the continuous synthesis of the antidote, and hence to the continuous expression of the toxin/antidote genetic module. If a cell happens to inactivate the plasmid or to escape its segregation during cell division, the ‘cured’ cell stops producing both the toxin and the antidote.

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