By Richard T. Maziarz MD (auth.), Richard T. Maziarz, Susan Slater (eds.)
Developed through the Blood and Marrow Transplant workforce at Oregon future health & technology college Knight melanoma Institute, this pocket advisor offers clinical administration instructions for hematopoietic stem phone transplant sufferers from the instant in their preliminary session through the transplant procedure. - It comprises symptoms for transplant, crucial information for patient/donor review; - suggestions for addressing issues in the course of and after transplant; - long-term stick to up care; - step by step directions for universal tactics and documentation directions. a vital instrument for services, this advisor provides a multidisciplinary method of info important for supplying caliber take care of your patients.
Read or Download Blood and Marrow Transplant Handbook: Comprehensive Guide for Patient Care PDF
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Additional resources for Blood and Marrow Transplant Handbook: Comprehensive Guide for Patient Care
24 J. 16 mg/kg (max 27 mg) if estimated GFR < 50 ml/min using Cockroft–Gault equation. – FDA approval for autologous setting in multiple myeloma and non-Hodgkin lymphoma. Not approved for allogeneic donors. b. Factors associated with poor mobilization i. Prior chemotherapy: increased cycles and duration of treatment ii. Prior radiation to marrow iii. Low pre-mobilization platelet count iv. Female gender v. , fludarabine vi. , prior melphalan in myeloma vii. Exposure to lenalidomide viii. Marrow involvement by lymphoma ix.
Disadvantages a. Requires operating room, spinal or general anesthesia b. Increased morbidity to donors i. Potential risks include pain, infection, blood loss, nerve and musculoskeletal damage ii. May require blood transfusions for young pediatric donors c. Slower neutrophil and platelet engraftment d. Increased risk relapse in some studies 4. Target cell dose a. Minimum 1 × 108 total mononuclear cells (TMNC)/kg body weight of recipient b. 3 PERIPHERAL BLOOD (PBSC) 1. Has largely replaced marrow as primary sources of HSCs a.
Irreversible ototoxicity ii. Delayed nausea and vomiting iii. Renal insufficiency iv. Electrolyte disturbance – acidosis, hyponatremia v. Neurotoxicity d. Patient care points i. Maintain adequate hydration 5. Cyclophosphamide (Cytoxan R ) a. Type: Alkylating agent b. Dose: 60 mg/kg/day IV daily for 2 days (based on IBW) incorporated into conventional hematologic malignancy conditioning regimens i. Aplastic anemia: 50 mg/kg IV daily for 4 days (based on IBW) is commonly used c. Toxicities i. Hemorrhagic cystitis ii.