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Biochemical Mechanisms in Heart Function by Jiří à imurda, Milena à imurdová, Pavel Bravený, Georges PDF

By Jiří à imurda, Milena à imurdová, Pavel Bravený, Georges Christé (auth.), Ernst Georg Krause, Roland Vetter (eds.)

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25 40. 41. 42. 43. 44. 45. 46. sis due to intracellular Ca overload - a new principle in cardiac pathophysiology. In: Recent Advances in Studies on Cardiac Structure and Metabolism. Myocardial Biology 4: 563-580, University Park Press, Baltimore, 1974 Fleckenstein A: Myocardschutz durch Calziumantagonisten In: H. Just, Tschirkov A und V. ). Kalziumantagonisten zur Kardioplegie und Myokardprotektion in der offenen Herzchirurgie. H. ). Calcium Antagonists and Cardiovascular Disease. Raven Press, New York: 1984 Kondo N: Electromechanical effects of A23187 on guinea-pig ventricular muscle: a dual action of A231 87.

Ogawa et al. [14] reported that the positive inotropic action of E-l 020 was not completely reversed by carbachol. Carbachol, a muscarinic receptor agonist, has been shown to inhibit the cAMP mediated positive inotropic actions [16,17]. The inability of carbachol to completely inhibit the inotropic effect ofE-l 020 suggests that E-l 020 may have actions as a Ca2+ sensitizer. While the mechanism by which PDE inhibition increases cardiac function is fairly well established [3], the Ca2+ sensitizing mechanisms of these drugs have not been fully elucidated.

J Physiol (Paris) 75: 463--505, 1979 15. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ: Protein measurement with the Folin phenol reagent. J BioI Chern 193: 265-275, 1951 16. Itzhaki RF, Gill DM: A micro-biuret method for estimating protein. Anal Biochem 9: 401--410,1964 17. Bradford M: A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-252, 1976 18. Towbin H, Staehelin T, Gordon J: Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

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