Download e-book for iPad: Bioactive Compounds from Marine Extremophiles by Lesley-Ann Giddings, David J. Newman

By Lesley-Ann Giddings, David J. Newman

​This SpringerBrief sheds new mild on bioactive fabrics from marine extremophiles. It offers with all features of the chemical substances produced by way of organisms residing less than severe stipulations that could have power as medicinal drugs or result in novel medications for human use.

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Extra info for Bioactive Compounds from Marine Extremophiles (SpringerBriefs in Microbiology / Extremophilic Bacteria)

Example text

Arenicola CNS-205 genome available and chemical synthesis, additional modifications to the saliniketal core structure could possibly result in the production of more potent ornithine decarboxylase inhibitors or other bioactive metabolites. New structural types of secondary metabolites that selectively inhibit enzymes are commonly found in terrestrial environments and have also been isolated from marine microorganisms. A common mechanism of cancer drug resistance is the overexpression of the ABC transporter, P-glycoprotein (P-gp).

This company has also conducted a Phase IV study (NCT00891293) assessing the safety and efficacy in hypertriglyceridemic subjects treated with Antara, a cholesterol-reducing drug. gov. The University of Medicine and Dentistry of New Jersey in collaboration with the National Center for Complementary and Alternative Medicine is also evaluating ω-3 fatty acids for the treatment of autistic children (NCT00467818); however, there are no recent updates on the progress of this study. gov). Thus, Lovaza® may be used in the treatment for several other diseases unrelated to coronary artery disease.

By screening 3,000 strains of marine microorganisms, the serine protease inhibitors marinostatins B-1 (152) (Fig. 8), B-2, C-1, and C-2 were isolated from the eubacterium Alteromonas sp. from nearshore seawater of Japan. The marinostatins are low molecular weight 12 (152 and marinostatin C-1)- and 14-residue (marinostatins B-2 and C-2) peptides consisting of the amino acids, such as aspartic acid, threonine, serine, glutamic acid, proline, alanine, methionine, tyrosine, phenylalanine, and arginine.

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