By Lesley-Ann Giddings, David J. Newman
This SpringerBrief sheds new mild on bioactive fabrics from marine extremophiles. It bargains with all facets of the chemical substances produced by means of organisms dwelling less than severe stipulations that could have capability as medicines or bring about novel medicines for human use.
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A dialogue of the chemicals produced by way of organisms dwelling below severe stipulations that could have power as medicines or results in novel medications for human use. This SpringerBrief bargains with bioactive fabrics from terrestrial extremophiles.
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Additional resources for Bioactive Compounds from Marine Extremophiles
Cyclomarin A O OH O N N H N O N N HO O O NH O HO O O O n O HN NH NH O O H N O NH NH O O NH O O O O NH HN O NH N O O 166. Arenamide A; n = 3 167. Arenamide B; n = 1 165. Cyclomarin C 164. Cyclomarin B O HN H N O NH N O NH O H N O O O N C3' H S NH O H N HN O HN H N O O OH O O O O N C3' H OH O O R C1''' N C3' H O C1''' C7 O R O H N OH O 172. Splenocin D; R = CH2CH3 173. Splenocin E; R = CH2(CH2)2CH3 174. Splenocin F; R = CH2(CH2)3CH3 175. Splenocin G; R = CH2(CH2)4CH3 176. Splenocin H; R = CH2CH(CH3)(CH2)3CH3 177.
Lipoxazolidinone B; R1 = R2 = CH2CH3 132. Lipoxazolidinone C; R1 = H, R2 = CH2CH3 O O HO H O Cl H Cl H HO 145. 3-Chloro-10a-(3-chloro-6-hydroxy-2,2,6trimethylcyclohexylmethyl)-6,8-dihydroxy2,2,7-trimethyl-4,4a-tetrahydro-2Hbenzo[g]chromene-5,10-dione O H O Cl H 146. 3-Chloro-10a-(3-chloro-6-hydroxy-2,2,6trimethylcyclohexylmethyl)-6,8dihydroxy-2,2,7-trimethyl-3,10adihydro-2H-benzo[g]chromene5,10-dione O OH O Cl H 147. 3-Chloro-10a-(3-chloro-6-hydroxy-2,2dimethyl-6-methylenecyclohexylmethyl)-6,8-dihydroxy2,2,7-trimethyl-2H-benzo[g]-chromene-5,10-dione OH OH OH O H2 N HO O O C12 C 11 S OH OH OH OH OH OH 151.
Compound 179 has been approved by the FDA and is currently sold as a nutraceutical for the treatment of hyperlipidemia. Eicosapentaenoic acid 179 is still being evaluated in several clinical studies. As of October 2014, the International Clinical Trials Registry Program has 22 trials listed as currently recruiting patients for treatment with either eicosapentaenoic acid alone or in combination with other fatty acids. The Department of Cardiology at Keio University School of Medicine is currently recruiting patients to evaluate the effects of compound 179 on left ventricular function in patients diagnosed with nonischemic cardiomyopathy (JPRN-UMIN000013609).