Download e-book for iPad: Bioactive Compounds from Marine Extremophiles by Lesley-Ann Giddings, David J. Newman

By Lesley-Ann Giddings, David J. Newman

​This SpringerBrief sheds new mild on bioactive fabrics from marine extremophiles. It bargains with all facets of the chemical substances produced by means of organisms dwelling less than severe stipulations that could have capability as medicines or bring about novel medicines for human use.

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Additional resources for Bioactive Compounds from Marine Extremophiles

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Cyclomarin A O OH O N N H N O N N HO O O NH O HO O O O n O HN NH NH O O H N O NH NH O O NH O O O O NH HN O NH N O O 166. Arenamide A; n = 3 167. Arenamide B; n = 1 165. Cyclomarin C 164. Cyclomarin B O HN H N O NH N O NH O H N O O O N C3' H S NH O H N HN O HN H N O O OH O O O O N C3' H OH O O R C1''' N C3' H O C1''' C7 O R O H N OH O 172. Splenocin D; R = CH2CH3 173. Splenocin E; R = CH2(CH2)2CH3 174. Splenocin F; R = CH2(CH2)3CH3 175. Splenocin G; R = CH2(CH2)4CH3 176. Splenocin H; R = CH2CH(CH3)(CH2)3CH3 177.

Lipoxazolidinone B; R1 = R2 = CH2CH3 132. Lipoxazolidinone C; R1 = H, R2 = CH2CH3 O O HO H O Cl H Cl H HO 145. 3-Chloro-10a-(3-chloro-6-hydroxy-2,2,6trimethylcyclohexylmethyl)-6,8-dihydroxy2,2,7-trimethyl-4,4a-tetrahydro-2Hbenzo[g]chromene-5,10-dione O H O Cl H 146. 3-Chloro-10a-(3-chloro-6-hydroxy-2,2,6trimethylcyclohexylmethyl)-6,8dihydroxy-2,2,7-trimethyl-3,10adihydro-2H-benzo[g]chromene5,10-dione O OH O Cl H 147. 3-Chloro-10a-(3-chloro-6-hydroxy-2,2dimethyl-6-methylenecyclohexylmethyl)-6,8-dihydroxy2,2,7-trimethyl-2H-benzo[g]-chromene-5,10-dione OH OH OH O H2 N HO O O C12 C 11 S OH OH OH OH OH OH 151.

Compound 179 has been approved by the FDA and is currently sold as a nutraceutical for the treatment of hyperlipidemia. Eicosapentaenoic acid 179 is still being evaluated in several clinical studies. As of October 2014, the International Clinical Trials Registry Program has 22 trials listed as currently recruiting patients for treatment with either eicosapentaenoic acid alone or in combination with other fatty acids. The Department of Cardiology at Keio University School of Medicine is currently recruiting patients to evaluate the effects of compound 179 on left ventricular function in patients diagnosed with nonischemic cardiomyopathy (JPRN-UMIN000013609).

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