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Download PDF by Hernandes M. E.: Ae -codimension of germs of analytic curves

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The pros and cons of these are elegantly discussed by Alix-Panabières and Pantel [134] and in the following chapters of this book. It is not yet clear which approach will provide the best capture, which also will depend on specifi application needs. Another major issue is that current methods for CTC detection result in capture of tumor cells of which the majority are apoptotic [57–59]. It is important to have an alternative procedure of isolating viable CTCs that are responsible for metastases and characterizing this population.

Also, isolated DTCs can remain viable and some can be propagated in culture while maintaining the original 16 CIRCULATING TUMOR CELLS AND HISTORIC PERSPECTIVES mutational status [139, 149, 150]. They may serve as a resource for investigating new drug therapies. Recently, improved techniques for propagating CTCs in culture represent a major step forward for facilitating both in vitro and in vivo personalized drug testing [151–153]. There are already several examples of genotypic analyses that could eventually impact drug selection on individual patients.

K. (1989) Prospects for the treatment of B cell tumors using idiotypic vaccination. International Reviews of Immunology, 4, 271–310. 11. J. (1990) Anti-idiotypic therapy of leukemias and lymphomas. Chemical Immunology, 48, 126–166. 12. L. et al. (1985) Emergence of idiotype variants during treatment of B-cell lymphoma with anti-idiotype antibodies. New England Journal of Medicine, 312, 1658–1665. 13. Levy, R. A. (1990) Therapy of lymphoma directed at idiotypes. Journal of the National Cancer Institute Monographs, 10, 61–68.

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