By K. Thapar, K. Kovacs, E. R. Laws (auth.), L. Symon, L. Calliauw, F. Cohadon, V. V. Dolenc, J. Lobo Antunes, H. Nornes, J. D. Pickard, H.-J. Reulen, A. J. Strong, N. de Tribolet (eds.)
As an addition to the eu postgraduate education process for younger neurosurgeons we started to post in 1974 this sequence of Advances and Technical criteria in Neurosurgery which used to be later backed by means of the ecu organization of Neurosurgical Societies. This sequence used to be fust mentioned in 1972 at a mixed assembly of the Italian and German Neurosurgical Societies in Taormina, the founding fathers of the sequence being Jean Brihaye, Bernard Pertuiset, Fritz Loew and Hugo KrayenbUhl. hence have been proven the rules of ecu co operation that have been born from the ecu spirit, flourished within the eu organization, and feature all through been linked to this sequence. the truth that the English language is definitely with a purpose to changing into the foreign medium at ecu medical meetings is a smart asset when it comes to mutual figuring out. as a result we now have determined to post all contributions in English, whatever the local language of the authors. All contributions are submitted to the total editorial board prior to publi cation of any quantity. Our sequence isn't meant to compete with the courses of unique medical papers in different neurosurgical journals. Our goal is, fairly, to offer fields of neurosurgery and similar components during which very important fresh advances were made. The contributions are written by way of experts within the given fields and represent the fust a part of every one volume.
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Extra resources for Advances and Technical Standards in Neurosurgery
Whereas slow progressive growth is the rule, a minority of null cell adenomas (5 per cent) have an acute presentation with so rapid a clinical evolution that apoplexy may be suspect. In up to 40 per cent of null cell adenomas and oncocytomas, gross invasion of parasellar structures is evident radiologically and/or intra-operatively (Scheithauer 1986a). Most null cell adenomas are chromophobic lesions and cannot be distinguished from other sparsely granulated lesions without immunohistochemical studies.
Whereas mean AgNOR counts in some recurrent and invasive pituitary adenomas have been found to be higher than in noninvasive tumors, the correlation has not been consistently observed among all invasive adenomas studied (Stefaneanu et al. 1989). This technique, while of some scientific interest, has not proven practically informative in predicting the behaviour of pituitary adenomas. The search for a pituitary specific proliferation marker remains an active area of pursuit. The presence of various antigens and novel proteins has been documented in pituitary tumor tissue such as cytokeratins (Ironside et al.
1988, Joensuu and Klemi 1988). Neither the DNA content nor S-phase fractions, nor aneuploidy in pituitary adenomas correlates well with invasiveness, recurrence, or overall aggressiveness in pituitary adenomas (Joensuu and Klemi 1988). S-phase fractions have also been determined in situ following the in vivo administration ofbromodeoxyuridine (BrDU), a thymidine analog (Nagashima et al. 1986). The incorporated BrDU in tumor tissue is revealed by immunohistochemistry using antiBrDU antibody. 5 per cent.