By Dimitrios A. Linos, Jon A. van Heerden
- Over two hundred beautiful illustrations, starting from intraoperative pictures, line drawings, diagnostic photographs, pathology slides, tables and graphs can be found to make every one case mentioned understandable and straightforward to follow.
- conventional and novel healing suggestions are introducedand the most recent advancements in minimal-access operative innovations are mentioned and reviewed.
- makes a speciality of a teamwork orientated strategy that identifies the required communications among the numerous scientific disciplines while facing adrenal problems.
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Extra info for Adrenal Glands Diagnostic Aspects and Surgical Therapy
The CRH-R2 subtype is expressed mainly in the peripheral vasculature and the heart, as well as in subcortical structures of the brain . It is notable that CRH availability is also regulated by specific binding of the peptide to CRH binding protein , with which it partially colocalizes in various tissues . 3 Hypothalamic-Pituitary-Adrenal Axis Fig. 2. A simplified, schematic representation of the intricate neuronal network that regulates the secretion of hypothalamic corticotropin-releasing hormone (CRH) from parvicellular neurons of the paraventricular nucleus (PVN).
J Immunol 151:1587–1596 30. Cunningham ET Jr,Bohn MC,Sawchenko PE (1990) The organization of adrenergic inputs to the paraventricular and supraoptic nuclei of the rat hypothalamus. J Comp Neurol 292:651–667 31. de Kloet ER, Vreugdenhil E, Oitzl MS, Joels M (1998) Brain corticosteroid receptor balance in health and disease. Endocr Rev 19:269–301 32. Demitrack M, Dale J, Straus S, et al (1991) Evidence of impaired activation of the hypothalamic-pituitaryadrenal axis in patients with chronic fatigue syndrome.
A simplified, schematic representation of the intricate neuronal network that regulates the secretion of hypothalamic corticotropin-releasing hormone (CRH) from parvicellular neurons of the paraventricular nucleus (PVN). Activation is represented by solid lines and inhibition by dashed lines (CRH, corticotropin-releasing hormone; ACTH, corticotropin; POMC, pro-opiomelanocortin; LC/NE,locus ceruleus/norepinephrine-sympathetic system; AVP,arginine vasopressin; GABA,g-aminobutyric acid; BZD,benzodiazepine) At the level of the anterior pituitary, CRH is the most potent but not the sole regulator of the corticotroph ACTH secretion.