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New PDF release: A calcium-based phantom bursting model for pancreatic islets

By Richard Bertram, Arthur Sherman

Insulin-secreting β-cells, situated in the pancreatic islets of Langerhans, are excitable cells that produce common bursts of motion potentials while prompted via glucose. the program has been the point of interest of mathematical research for 2 a long time, spawning an array of mathematical versions. lately, a brand new classification of types has been brought known as 'phantom bursters' [Bertram et al. (2000) Biophys. J. seventy nine, 2880-2892], which bills for the big variety of burst frequencies exhibited by means of islets through the interplay of multiple sluggish technique. right here, we describe one implementation of the phantom bursting mechanism within which intracellular Ca2+ controls the oscillations via either direct and oblique detrimental suggestions pathways. We express how the version dynamics may be understood via an extension of the fast/slow research that's commonly hired for bursting oscillations. From this angle, the version uses a number of levels of freedom to generate the complete variety of bursting oscillations exhibited by way of β-cells. The version additionally debts for quite a lot of experimental phenomena, together with the ever-present triphasic reaction to the step elevation of glucose and responses to perturbations of inner Ca2+ shops. even though it isn't shortly a whole version of all β-cell houses, it demonstrates the layout rules that we count on will underlie destiny growth in β-cell modeling.

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Extra resources for A calcium-based phantom bursting model for pancreatic islets

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